Pour Me A Little More of That Red Wine; It’s Good For Me!

Posted on July 3, 2008. Filed under: health, wellbeing | Tags: , , , |

A large glass of red wine contains about three...

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For years we have been hearing about how good Red Wine is for us and lucky for me I am only sensitive to white wine (it gives me headaches), so the lastest news will justify my having a little more on occasion ;).

Actually I don’t drink that much, but I have to tell you my Gran does, she is now 87 and she has decided that she has to have at least one glass of red a day. She says that at her age it isn’t like she’s going to be driving and it’s good for her.  One glass for lunch and one with dinner and lately I am sure the bottle has been going down a lot quicker than it should 🙂 So perhaps they’re extra big glasses.

According to the research it could be why my Gran has lived so long and still has most of her cognitive powers?! Here’s some of the research information:

“Earlier studies showed that reducing calorie intake by 30%, or eating a nutritious diet every other day, can delay the onset of age-related diseases, improve stress resistance, and decelerate functional decline, the researchers said. Although dietary restriction has beneficial effects in humans, such a diet is unlikely to be widely adopted and would pose a significant risk to the frail, critically ill, or the elderly.

Therefore, the researchers are on a quest for “dietary restriction mimetic” compounds that provide some of the benefits without cutting calories. One contender has been compounds like resversatrol that activate SIRT1, a protein linked to long life in many species, from yeast to mammals.

Resveratrol produced changes in the gene expression profiles of key metabolic tissues, including liver and muscle, that closely resemble those induced by dietary restriction, they report. Overall, the animals’ health improved under all dietary conditions, as reflected by a reduction of osteoporosis, cataracts, vascular dysfunction, and declines in motor coordination. However, the mice lived longer only when they were fed a high-calorie diet, consistent with earlier reports.

” In conclusion, long-term resveratrol treatment of mice can mimic transcriptional changes induced by dietary restriction and allow them to live healthier, more vigorous lives,” they wrote. “In addition to improving insulin sensitivity and increasing survival in [high-calorie fed] mice, we show that resveratrol improves cardiovascular function, bone density, and motor coordination, and delays cataracts, even in nonobese rodents. Together, these findings confirm the feasibility of finding an orally available dietary restriction mimetic.”

Resveratrol treatment is already being tested in clinical trials for type II diabetes, the researchers noted, and more potent molecules with effects similar to resveratrol are also under development.” Physorg

Now this doesn’t mean guzzle it like my Gran! It does mean though you don’t have to feel guilty any more, it’s good for you!

Be Fit! Be Well! do it online…

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2 Responses to “Pour Me A Little More of That Red Wine; It’s Good For Me!”

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The amount of Reveratrol in a glass of red wine is almost negligible in terms of longevity. However, the amount of proanthocianidins is healthier and in particular will help protect the small blood vessels from hyperpermeability (microangiopermeability) thus reducing the rsik of cerebral bleefing and ptoectin eyes and kdneys , escpecially in diabetics. Hereunder recent research:
Researchers have shown that red wine and tea may both hold promise for regulating the blood sugar of people with type 2 diabetes.

Levels of blood glucose rise sharply in patients with type 2 diabetes immediately following a meal. Red wine and tea contain antioxidants that help to slow the passage of glucose through the small intestine and into the bloodstream, which can prevent the blood sugar spike.

Keeping blood sugar levels normal is one of the key challenges of managing diabetes; doing so can help prevent the disease from contributing to heart disease and high blood pressure as well as damaging the eyes, kidneys, nerves and blood vessels.

Sources:

* Science Daily April 3, 2008

Dr Louise Connelly, from Imperial College, who has looked at the effects of resveratrol on lung disease, said that the chemical did not stay in the body long enough to have any effects.

“The resveratrol molecule is very quickly removed from the bloodstream metabolised by the liver.

“In order to have any effect, you would have to drink literally gallons of wine, and that is not recommended.”

She said that the only way for humans to experience its effects would be the development of a form of the chemical which overcame this problem.

Abstract

Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose of resveratrol (4.9 mg kg−1 day−1), or a calorie restricted (CR) diet and examined genome-wide transcriptional profiles. We report a striking transcriptional overlap of CR and resveratrol in heart, skeletal muscle and brain. Both dietary interventions inhibit gene expression profiles associated with cardiac and skeletal muscle aging, and prevent age-related cardiac dysfunction. Dietary resveratrol also mimics the effects of CR in insulin mediated glucose uptake in muscle. Gene expression profiling suggests that both CR and resveratrol may retard some aspects of aging through alterations in chromatin structure and transcription. Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some aspects of CR.

Citation: Barger JL, Kayo T, Vann JM, Arias EB, Wang J, et al. (2008) A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice. PLoS ONE 3(6): e2264. doi:10.1371/journal.pone.0002264

Editor: Daniel Tomé, AgroParisTech, France
NOTE: the dosage in Mice of 4.9mg/Kg will give you some idea of a possible dose/therapeutic effect.

Thank you for your great comment, Daniel. As a Homoeopath as well as my other credentials I also subscribe to the theory that a little over time will have the needed effect, although it is also possible to purchase therapeutic grade supplements and maintain your dose for best effect. My headline and quip was meant to be in jest!

Here are some more interesting pieces of information on Resveratrol and the amazing research that is coming out about it on an almost daily basis.

‘”Resveratrol, a compound present in grapes and red wine, reduces the number of fat cells and may one day be used to treat or prevent obesity, according to a new study. The results will be presented at The Endocrine Society’s 90th Annual Meeting in San Francisco.
Past research found that resveratrol protected laboratory mice that were fed a high-calorie diet from the health problems of obesity, by mimicking the effects of calorie restriction. Researchers at the University of Ulm in Germany wanted to know if resveratrol could mimic the effects of calorie restriction in human fat cells by changing their size or function. “(PhysOrg.com. June 16, 2008)

“Researchers at the University of Alabama at Birmingham (UAB) have found that nutrients in red wine may help reduce the risk of developing prostate cancer.
The study involved male mice that were fed a plant compound found in red wine called resveratrol, which has shown anti-oxidant and anti-cancer properties. Other sources of resveratrol in the diet include grapes, raspberries, peanuts and blueberries.

In the study resveratrol-fed mice showed an 87 percent reduction in their risk of developing prostate tumors that contained the worst kind of cancer-staging diagnosis. The mice that proved to have the highest cancer-protection effect earned it after seven months of consuming resveratrol in a powdered formula mixed with their food.” (PhysOrg, Aug 31, 2008)

“Early laboratory research has shown that resveratrol, a common dietary supplement, suppresses the abnormal cell formation that leads to most types of breast cancer, suggesting a potential role for the agent in breast cancer prevention. Resveratrol is a natural substance found in red wine and red grapes. It is sold in extract form as a dietary supplement at most major drug stores.
“Resveratrol has the ability to prevent the first step that occurs when estrogen starts the process that leads to cancer by blocking the formation of the estrogen DNA adducts. We believe that this could stop the whole progression that leads to breast cancer down the road,” said Eleanor G. Rogan, Ph.D., a professor in the Eppley Institute for Research in Cancer and Allied Diseases at the University of Nebraska Medical Center.” (PhysOrg, July 7, 2008)

NOTE: Although researchers experimented with up to 100 µmol/L of resveratrol, the suppression of DNA adducts was seen with 10 µmol/L. A glass of red wine contains between 9 and 28 µmol/L of resveratrol.


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